菌毒炎并治法对脓毒症大鼠免疫相关基因的影响
张照健;何英;李志军;
摘要(Abstract)：
目的:观察菌毒炎并治对脓毒症大鼠免疫相关基因的影响,探讨其免疫调节机制。方法:将大鼠分为模型组、菌毒炎组、对照组。用盲肠结扎穿孔术复制脓毒症模型。菌毒炎组腹腔注射抗生素、血必净注射液,凉膈散煎剂灌胃;对照组和模型组腹腔注射生理盐水。杀死大鼠后用芯片检测肝基因,筛选差异基因,查询功能并分类。结果:检测到差异表达的已知基因48个,其中免疫相关基因7个。结论:菌毒炎并治法对于脓毒症大鼠的改善可能与其对免疫相关基因的调控有关。
关键词(KeyWords)： 基因芯片;菌毒炎并治法;脓毒症;免疫相关基因;大鼠
基金项目(Foundation): 脓毒症大鼠基因改变及三证三法治疗机制实验研究天津市卫生局中医处资助项目(项目编号:07003)
作者(Author): 张照健;何英;李志军;
Email:
DOI: 10.13463/j.cnki.jlzyy.2010.02.036
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