常翔,杨琳,李敏,雷亚玲

• 1:西安市中医医院
• 2:陕西省中医医院

摘要(Abstract)：

目的探讨当归芍药散对小胶质细胞活化状态的影响。方法采用CCK-8法和实时荧光定量PCR(Real-time PCR)检测不同浓度的当归芍药散对小胶质细胞活力的影响,及其对小胶质细胞不同活化状态生物标志物表达的影响。结果当归芍药散可以促进小胶质细胞的增殖,且呈现时间、剂量依赖性;当归芍药散可下调TNF-α mRNA的表达水平,同时上调Arg1 mRNA的表达水平。结论当归芍药散可促进小胶质细胞的增殖,并调控其活化状态向M2型转化,促进其对Aβ的吞噬作用从而改善阿尔兹海默病。

关键词(KeyWords)： 阿尔兹海默病;当归芍药散;小胶质细胞;活化状态

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年项目(81704131)

作者(Author): 常翔,杨琳,李敏,雷亚玲

DOI: 10.13463/j.cnki.jlzyy.2020.07.029

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