丹红共煎剂对乳鼠肥大心肌细胞ATP影响的研究Huoxue treatment with Danhong Gongjianji effect on neonatal rat cardiomyocytes hypertrophy of ATP
索红亮;孙治霞;柴松波;韩丽华;王振涛;
摘要(Abstract):
目的观察以丹红共煎剂为代表的活血治法对乳鼠肥大心肌细胞ATP的影响,进而观察活血治法在干预心肌细胞能量代谢中的作用,为活血中药防治心衰提供依据。方法体外培养乳鼠心肌细胞,利用血管紧张素Ⅱ(AngⅡ)模拟心衰大鼠心肌细胞环境,制作肥大心肌细胞模型,观察丹红共煎剂含药血清对心肌细胞细胞活性及ATP的影响。结果丹红共煎剂含药血清干预12、24、48 h,干预组心肌细胞活性高于模型组,24 h各组ATP含量无明显变化,48 h时干预组ATP含量低于模型组。结论丹红共煎剂可改善AngⅡ所致肥大心肌细胞的能量代谢。
关键词(KeyWords): 丹红共煎剂;活血;心衰;能量代谢;ATP
基金项目(Foundation): 郑州市科技发展计划项目(郑科计[2012]2号,121PPTGG509-11)
作者(Author): 索红亮;孙治霞;柴松波;韩丽华;王振涛;
Email:
DOI: 10.13463/j.cnki.jlzyy.2016.07.020
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