轻度认知损害与简易精神状态检查分项相关性分析及其中医防治研究Investigation of Correlation Between Mild Cognitive Impairment and Subitem of MMSE and the Research on Prevention of Chinese Medicine
俞璐;李敏琤;夏明;
摘要(Abstract):
目的探讨上海中医药大学附属普陀临床医学院门诊及住院病人不同分型轻度认知功能损害(MCI)和不同体质MCI患者与简易精神状态检查(MMSE)量表分项的相关性。方法根据2004年轻度认知功能损害(MCI)国际工作组制订的诊断标准,选择163例MCI患者并进行aMCI(遗忘型)和naMCI(非遗忘型)分型,收集调查对象的一般资料、神经心理测试量表、临床表现和舌脉,根据王琦等制订的9种基本中医体质类型的分类及其诊断表述依据判断中医体质类型。结果纳入的163例MCI患者中,aMCI 126例,naMCI 37例。MMSE量表中注意力及计算力、回忆力与aMCI相关(P <0.05),时间定向力、注意力及计算力、书写/叙述能力与naMCI相关(P <0.05)。MCI平和质、气虚质、阳虚质、阴虚质、湿热质、血瘀质及气郁质患者MMSE量表中注意力及计算力的得分率最低,痰湿质患者记忆力得分率最低。结论注意力及计算力、回忆力是aMCI较易损害的认知领域;时间定向力、注意力及计算力、书写/叙述能力是naMCI较易损害的认知领域。平和质、气虚质、阳虚质、阴虚质、湿热质、血瘀质及气郁质患者认知损害领域集中在注意力及计算力,痰湿质患者集中在记忆力。研究有利于识别MCI早期认知功能变化,为MCI中医防治提供有益线索。
关键词(KeyWords): 轻度认知功能损害;简易精神状态检查分项;中医防治
基金项目(Foundation): 国家自然科学基金资助项目(81503370);; 上海市青年医师培养资助计划项目;; 上海市普陀区中医临床重点专科建设项目(PTZYLCZDZK-2017003)
作者(Author): 俞璐;李敏琤;夏明;
Email:
DOI: 10.13463/j.cnki.jlzyy.2019.06.018
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