电针对WKY大鼠抑郁样行为及海马GluR1的影响Effects of electroacupuncture on depressive behavior and hippocampal GluRl of WKY rats
陈泽钦;董波;黄丽;韩栩珂;徐世芬;
摘要(Abstract):
目的通过电针"百会""印堂"观察对抑郁大鼠行为及海马Glu R1的影响。方法 21只雄性WKY大鼠被随机分为电针组、假针组和模型组;雄性Wistar大鼠7只分为正常组。电针组取穴为"百会""印堂",假针组给予安慰治疗,模型组和正常组常规饲养,21 d后测定各组大鼠糖水消耗量(SPT)、强迫游泳实验(FST)的改变,用Western blot检测大鼠海马谷氨酸受体(glutamate receptor1,Glu R1)蛋白表达。结果电针组蔗糖水喜好率明显高于假针组(P<0.05),正常组蔗糖水喜好率高于模型组(P<0.05);强迫游泳试验中电针组和正常组不动时间少于假针组和模型组(P<0.05);海马Glu R1的表达量中,电针组高于假针组(P<0.05),正常组高于模型组(P<0.01)。结论电针对WKY抑郁大鼠的行为学核心症状有明显的改善作用,其作用可能与海马Glu R1的表达增加有关。
关键词(KeyWords): 抑郁症;电针;行为学;WKY大鼠
基金项目(Foundation): 上海市教委科研创新重点项目(编号:2014zz116);; 上海市卫生和计划生育委员会项目(编号:ZY3-CCCX-3-3022)
作者(Author): 陈泽钦;董波;黄丽;韩栩珂;徐世芬;
Email:
DOI: 10.13463/j.cnki.jlzyy.2017.02.017
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