王星;

• 1:宝鸡市中医医院

摘要(Abstract)：

目的观察活血补肝肾汤对膝骨性关节炎患者视觉模拟(VAS)评分、白细胞介素-1β(IL-1β)、IL-6和血液黏滞度的影响。方法选取膝骨性关节炎患者63例,按用药方法随机分为对照组(n=29)和试验组(n=34)。2组患者予以常规西医治疗,试验组患者在此基础上予以活血补肝肾汤口服。结果治疗前2组患者的各项指标比较均无统计学意义(P>0.05)。治疗10周后,试验组的VAS评分、IL-1β、IL-6和血液黏滞度明显低于对照组,2组比较差异均有统计学意义(P<0.05);试验组总有效率为91.2%,对照组总有效率为72.4%,试验组明显高于对照组(P<0.05)。结论活血补肝肾汤治疗膝骨性关节炎能有效改善患者的临床症状及炎症指标。

关键词(KeyWords)： 活血补肝肾汤;膝骨性关节炎;白细胞介素;血液黏滞度

Abstract:

Keywords:

基金项目(Foundation): 陕西省中医药管理局计划项目(201679)

作者(Author): 王星;

Email:

DOI: 10.13463/j.cnki.jlzyy.2018.07.015

参考文献(References)：

• [1]刘泽庚,姚红艳,吴官保,等.超微肿痛贴治疗膝骨性关节炎的疗效及其对血清OPN的影响[J].湖南中医药大学学报,2014,34(3):43-45.
• [2]Levinger P,Dunn J,Bifera N,et al.High-speed resistance training and balance training for people with knee osteoarthritis to reduce falls risk:study protocol for a pilot randomized controlled trial[J].Trials,2017,18(1):384.
• [3]Datta P,Zhang Y,Parousis A,Sharma A,et al.High-fat dietinduced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature[J].Sci Rep,2017,7(1):8205.
• [4]李云涛,刘爱峰,金鸿宾,等.海桐伸筋透骨汤治疗膝骨性关节炎的临床疗效观察[J].天津中医药,2016,33(11):665-667.
• [5]Wang Y,Yu D,Liu Z,et al.Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix[J].Stem Cell Res Ther,2017,8(1):189.
• [6]Niazvand F,Khorsandi L,Abbaspour M,et al.Curcumin-loaded poly lactic-co-glycolic acid nanoparticles effects on monoiodoacetate-induced osteoarthritis in rats[J].Vet Res Forum,2017,8(2):155-161.
• [7]刘兴利,赵亮,徐宁达,等.中药治疗早、中期膝骨性关节炎[J].长春中医药大学学报,2014,30(5):918-919.
• [8]Wang Y,Shimmin A,Ghosh P,et al.Safety,tolerability,clinical,and joint structural outcomes of a single intraarticular injection of allogeneic mesenchymal precursor cells in patients following anterior cruciate ligament reconstruction:a controlled double-blind randomised trial[J].Arthritis Res Ther,2017,19(1):180.
• [9]Amano K,Li AK,Pedoia V,et al.Effects of Surgical Factors on Cartilage Can Be Detected Using Quantitative Magnetic Resonance Imaging After Anterior Cruciate Ligament Reconstruction[J].Am J Sports Med,2017,45(5):1075-1084.
• [10]李姗,罗庆禄,邱艺斌,等.复方三七消痛软膏治疗兔膝骨性关节炎的疗效及其对软骨细胞caspase-3表达的影响[J].吉林中医药,2016,36(4):394-397.
• [11]Adeyemi WJ,Olayaki LA.Effects of single or combined induction of diabetes mellitus and knee osteoarthritis on some biochemical and haematological parameters in rats[J].Exp Mol Pathol,2017,103(2):113-120.
• [12]裴开源,刘爱峰,杨硕,等.膝骨性关节炎步态分析研究进展[J].吉林中医药,2016,36(5):533-537.
• [13]张超凡,王新军,刘俊昌,等.陈元膏摩对膝骨性关节炎大鼠软骨Ⅰ、Ⅱ型胶原的影响[J].吉林中医药,2014,34(5):506-510.
• [14]Huang S,Li X,Tang Y,et al.Different patient satisfaction levels between the first and second knee in the early stage after simultaneous bilateral total knee arthroplasty(TKA):a comparison between subjective and objective outcome assessments[J].J Orthop Surg Res,2017,12(1):121.
• [15]于隽,熊俊.热敏灸治疗膝骨性关节炎临床疗效的系统评价与Meta分析[J].广州中医药大学学报,2015,35(1):60-66.
• [16]宰庆书,蒋长伟,岳耀升,等.鲁西南邹城市膝骨性关节炎的流行病学调查及早期阶梯性治疗[J].中国组织工程研究,2015,10(29):4609-4613.
• [17]Sazo-Rodríguez S,Méndez-Rebolledo G,Guzmán-Mu?oz E,et al.The effects of progressive neuromuscular training on postural balance and functionality in elderly patients with knee osteoarthritis:a pilot study[J].J Phys Ther Sci,2017,29(7):1229-1235.
• [18]张师侥,关雪峰.中医外治法治疗膝骨性关节炎最新进展[J].中国骨质疏松杂志,2016,22(7):907-911.
• [19]裴开源,刘爱峰,杨硕,等.膝骨性关节炎步态分析研究进展[J].吉林中医,2016,36(5):553.
• [20]韩江,王培民.中医外治膝骨性关节炎临床研究[J].长春中医药大学学报,2013,29(2):244.
• [21]Martel-Pelletier J,Raynauld JP,Mineau F,et al.Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging:an exploratory study[J].Arthritis Res Ther,2017,19(1):169.
• [22]郝军,赵文海,詹红生,等.整体辨证三期分治膝骨性关节炎300例随机对照临床研究[J].中医杂志,2014,55(2):121-124.