徐寒莹;李鹏飞;张影;徐鹏;王健;

• 1:长春中医药大学中医学院
• 2:长春中医药大学附属医院脑病中心

摘要(Abstract)：

多年来,我国中风患病率始终高于全球水平。作为造成我国成年人致死、致残的主要原因,中风病严重影响了人民生命健康与生活质量,为患者个人、家庭及社会发展带来沉重负担。肠道微生态作为近年来国内外学者的研究热点,与中风发病、治疗及预后存在密切关联。基于中医学中"脾胃运化"功能探讨肠道微生态与中风病的关联对于从脾胃防治中风具有重要意义,肠道微生态也为中医药防治中风病提供新的切入角度。

关键词(KeyWords)： 肠道微生态;脾胃;中风

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(2019YFC1709900);; 国家自然科学基金委员会资助面上项目(82474317);; 吉林省科技发展计划项目(20190905005SF);; 吉林省中医药科技项目(2020073)

作者(Author): 徐寒莹;李鹏飞;张影;徐鹏;王健;

Email:

DOI: 10.13463/j.cnki.jlzyy.2020.12.007

参考文献(References)：

• [1]CHEN R,XU Y,WU P,et al.Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota[J].Pharmacological research,2019(148):104403.
• [2]ZENG X,GAO X,PENG Y,et al.Higher Risk of Stroke Is Correlated With Increased Opportunistic Pathogen Load and Reduced Levels of Butyrate-Producing Bacteria in the Gut[J].Front Cell Infect Microbiol,2019(9):4.
• [3]KOETH R,WANG Z,LEVISON B,et al.Intestinal microbiota metabolism of L-carnitine,a nutrient in red meat,promotes atherosclerosis[J].Nature medicine,2013,19(5):576-585.
• [4]FARHANGI M,VAJDI M,ASGHARI-JAFARABADI M.Gut microbiota-associated metabolite trimethylamine N-Oxide and the risk of stroke:a systematic review and dose-response meta-analysis[J].Nutrition journal,2020,19(1):76.
• [5]NIE X,CHEN J,MA X,et al.A metagenome-wide association study of gut microbiome and visceral fat accumulation[J].Computational Structural Biotechnology Journal,2020(18):2596-2609.
• [6]王颢润,周杰,陈礼刚.肠道微生物与中枢神经系统疾病研究进展[J].中国神经精神疾病杂志,2018,44(9):58-61.
• [7]CHEN R,WU P,CAI Z,et al.Puerariae Lobatae Radix with chuanxiong Rhizoma for treatment of cerebral ischemic stroke by remodeling gut microbiota to regulate the brain-gut barriers[J].The Journal of nutritional biochemistry,2019 (65):101-114.
• [8]SINGH V,SADLER R,HEINDL S,et al.The gut microbiome primes a cerebroprotective immune response after stroke[J].Journal of Cerebral Blood Flow Metabolism,2018,38(8):1293-1298.
• [9]PATTERSON T,NICHOLSON S,WALLACE D,et al.Complex Feed-Forward and Feedback Mechanisms Underlie the Relationship Between Traumatic Brain Injury and the Gut-Microbiota-Brain Axis[J].Shock,2019,52(3):318-325.
• [10]WEN S,SHIM R,HO L,et al.Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke[J].Aging cell,2019,18(5):e12980.
• [11]LEE J,D’AIGLE J,ATADJA L,et al.Gut Microbiota-Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice[J].Circulation research,2020,127(4):453-465.