刘影哲;王春晓;潘祥宾;

• 1:黑龙江中医药大学附属第一医院
• 2:黑龙江中医药大学附属第二医院

摘要(Abstract)：

目的研究白虎加人参汤对糖尿病模型大鼠氧化应激TAOC水平及背根神经节(DRG)中TRPV1m RNA基因表达的影响。方法腹腔注射链脲佐菌素建立糖尿病大鼠模型。将造模成功大鼠随机分为模型对照组、白虎加人参汤组以及α-硫辛酸组。药物治疗8周后,采用酶联免疫法检测大鼠TAOC水平,RT-PCR法检测DRG中TRPV1 m RNA的表达。结果与模型对照组比较,白虎加人参汤组和α-硫辛酸组总抗氧化能力均升高(P<0.05),2组间比较,α-硫辛酸组TAOC水平更高,差异有统计学意义(P<0.05);白虎加人参汤组和α-硫辛酸组DRG中TRPV1 m RNA的表达与模型对照组比较均下调(P<0.01),组间比较差异无统计学意义(P>0.05)。结论白虎加人参汤能提高糖尿病大鼠血清TAOC水平,减轻氧化应激反应,具有一定的抗氧化能力,同时下调DRG中TRPV1 m RNA的表达,对糖尿病神经病变有一定的防治作用。

关键词(KeyWords)： 白虎加人参汤;糖尿病;氧化应激;TRPV1;大鼠

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省教育厅基金项目(12521508);; 黑龙江省自然科学基金项目(H201314)

作者(Authors): 刘影哲;王春晓;潘祥宾;

DOI: 10.13463/j.cnki.jlzyy.2018.08.022

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