李小娟;廉富;朱海燕;

• 1:天津中医药大学第二附属医院国家中医药管理局三级呼吸功能实验室

摘要(Abstract)：

目的观察麻芩咳喘合剂对哮喘慢性持续期患者呼出气一氧化氮水平的影响。方法支气管哮喘慢性持续期患者30例,随机分为治疗组14例,对照组16例。治疗组予以麻芩咳喘合剂口服,1剂/d,早晚温服;对照组吸入舒利迭(沙美特罗替卡松粉吸入剂)(50/250μg),1吸,2次/d,疗程1个月。观察治疗前后ACT评分、FENO、肺通气功能指标(包括FVC%、FEV1%、FEV1/FVC、PEF%)。采用IBM SPSS Statistics 19统计分析。结果治疗后2组患者症状均好转,ACT评分与疗前比较均具有统计学意义(P<0.001),组间比较无统计学意义;疗前2组患者呼出气一氧化氮水平升高明显,疗后均有明显下降,与疗前相比较具有统计学意义,疗后组间比较无统计学意义;2组患者肺通气功能均较治疗前好转,但组间及组内比较均无统计学意义。结论麻芩咳喘合剂治疗支气管哮喘慢性持续期能够改善患者症状,降低患者呼出气一氧化氮水平,控制气道炎症。

关键词(KeyWords)： 麻芩咳喘合剂;支气管哮喘;慢性持续期;呼出气一氧化氮;气道炎症

Abstract:

Keywords:

基金项目(Foundation): 天津市卫生局资助项目(11054)

作者(Author): 李小娟;廉富;朱海燕;

Email:

DOI:

参考文献(References)：

• [1]中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案)[J].中华哮喘杂志(电子版),2008,2(1):3-13.
• [2]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:6-7.
• [3]Bentley AM,Menz G,Stortz C,et al.Identification of T lymphocytes,macrophages,and activat edeosinophils in the bronchial mucosa in intrinsic asthma:relationship to symptoms and bronchial responsiveness[J].Am Rev Respir Dis,1992,146:500-506.
• [4]杨汀,王辰.气道高反应性与小气道阻塞关系的分析[J].医学理论与实践,2000,13(12):720-721.
• [5]Global Initiative For Asthma(GINA).Guide for asthma management andprevention.2008.
• [6]Karuri A R,Huang Y,Bodreddigari S,et al.SH-1,2-dithide-3-thione targets nuclear factor-kappaB to block expressionof inducible nitric-oxide synthase,prevents hypotension,and improves survival in endotoxemic rats[J].J Pharmacol Exp Ther,2006,317(1):61-67.
• [7]Li MO,Wan YY,Flavell RA.T cell-produced transforming growth factor betal controls Tcell tolerance and regulates Th1andTh17-cell ifferentiation[J].Immunity,2007,26(5):579-591.
• [8]Bat ra J,Prat ap S ingh T,Mabalirajan U,et al.Ass ociat ion of indu cible nit ric oxide syn thas e w ith asthma s everi ty,t otal s erumim munoglobu lin E and blood eosinoph il l evels[J].T horax,2007,62:16-22.
• [9]张焱,张庆荣.培土生金法对脾虚哮喘大鼠一氧化氮水平改变影响的实验研究[J].吉林中医药,2007,27(10):52-54.
• [10]Gerdt C,Riise,Kjell Tor'en,Anna-Carin Olin.Subjects in a Population Study with High Levels of FENO Have Associated Eosinophil Airway Inflammation[J].ISRN Allergy,2011(2011),1-6.
• [11]Green RH,Brightling CE,McKenna S,et al.Asthma exacerbations andsputum eosinophil counts:a randomised controlled trial[J].Lancet,2002,360:1715-1721.
• [12]Berry M A,Shaw D E,Green R H,et al.The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation:an observational study in adults with asthma[J].Clin Exp Allergy,2005,35:1175-1179.
• [13]Shaw DE,Berry MA,Thomas M,et al.The use of exhaled nitric oxide to guide asthma management:a randomized controlled trial[J].Am J Respir Crit Care Med,2007,176:231-237.
• [14]Jatakanon A,Lim S,Kharitonov S A,et al.Correlation between exhaled nitric oxide,sputum eosinophils,and methacholine responsiveness in patients with mild asthma[J].Thorax,1998,53:91-95.
• [15]Porsbjerg C,Lund T K,Pedersen L,et al.Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO[J].J Asthma,2009,46:606-612.
• [16]刘玮,魏葆琳.呼出气一氧化氮测定在哮喘诊断和治疗中的应用[J].长春中医药大学学报,2012,28(05):888-889.
• [17]于宗学,胡东明.中医药治疗哮喘优势展望[J].长春中医药大学学报,2013,29(5):941-942.
• [18]刘恩顺,孙增涛.麻芩咳喘合剂对支气管哮喘治疗效果及炎性物质的影响[J].天津中医药,2007,24(6):452-455.
• [19]马佐英,孙增涛,刘恩顺,等.麻芩咳喘合剂对哮喘豚鼠嗜酸性粒细胞及其阳离子蛋白的影响[J].天津中医药,2007,24(2):98-100.
• [20]刘恩顺,孙增涛.麻芩咳喘合剂治疗哮喘的临床疗效评价及机制研究[J].西部医学,2007,19(2):187-189.