任秋月;刘鹏;姚蓉飞;常柏;

• 1:天津中医药大学
• 2:天津医科大学朱宪彝纪念医院

摘要(Abstract)：

目的观察抵挡汤早期干预改善2型糖尿病大鼠大血管病变纤维化的作用,探讨其机制。方法采用高脂饲料喂养联合链脲佐菌素(STZ)方法制备2型糖尿病大鼠模型,抵挡汤早期干预组、中期干预组、晚期干预组分别于成模前4周、成模时、成模后4周予抵挡汤灌胃,氨基胍组、吡格列酮组于成模时分别予氨基胍、吡格列酮灌胃,正常对照组予等剂量生理盐水灌胃,于24周结束。采用ELISA法检测各组大鼠血清中基质金属蛋白酶(MMPs)、基质金属蛋白酶组织抑制因子(TIMPs)蛋白表达。结果与糖尿病组相比,除抵挡汤晚期干预组外,各干预组MMPs蛋白表达增加,TIMPs表达降低(P<0.05),其中MMP-2、MMP-8、MMP-9增加程度以及TIMP-1、TIMP-2降低程度均以抵挡汤早期干预组最显著(P<0.05),MMP-9/TIMP-1、MMP-2/TIMP-2以抵挡汤早期干预组升高最显著(P<0.05)。结论抵挡汤早期干预可通过上调MMPs/TIMPs,改善细胞外基质合成分解失衡,延缓2型糖尿病大血管病变纤维化进展。

关键词(KeyWords)： 抵挡汤;2型糖尿病;大血管病变;纤维化;基质金属蛋白酶;基质金属蛋白酶组织抑制因子

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目资助(81473622;81973614)

作者(Author): 任秋月;刘鹏;姚蓉飞;常柏;

Email:

DOI: 10.13463/j.cnki.jlzyy.2020.08.027

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