人参皂苷Rg3对鼻咽癌放疗患者CD 80/86表达及细胞免疫功能的影响Effect of Rg3 on the expression of CD 80/86 and cellular immune function in patients with nasopharyngeal carcinoma after radiotherapy
陈洪志;罗花南;权博源;易春曦;
摘要(Abstract):
目的探讨人参皂苷Rg3对鼻咽癌放疗患者CD 80/86表达及细胞免疫功能的影响。方法选取鼻咽癌放疗患者60例作为研究对象,将其随机分为对照组和观察组,每组30例。放疗结束后分离收集2组患者外周血淋巴细胞。MTT法检测淋巴细胞增殖,流式细胞仪检测淋巴细胞亚群间接ELISA法检测Ig G、Ig M抗体水平及Th1/Th2、CD80、CD86细胞因子表达。结果 Rg3能够促进鼻咽癌放疗患者淋巴细胞增殖,上调CD4+、CD4+/CD8+、Ig G、CD 80/86、Ig M、IL-2,下调IL-6、CD8+,并呈现剂量依赖性。结论人参皂苷单体Rg3能够明显增强鼻咽癌放疗患者外周血淋巴细胞免疫功能,提示其可作为潜在的免疫增强剂应用于鼻咽癌患者放射治疗过程。
关键词(KeyWords): 人参皂苷Rg3;鼻咽癌;放疗;淋巴细胞
基金项目(Foundation): 国家自然科学基金(81402246)
作者(Author): 陈洪志;罗花南;权博源;易春曦;
Email:
DOI: 10.13463/j.cnki.jlzyy.2017.12.007
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