清肝降浊颗粒治疗非酒精性脂肪性肝病大鼠脂质沉积的作用机制研究Effect and Mechanism of Qinggan Jiangzhuo Granule on Rats with Non-alcoholic Fatty Liver Disease
王胜军;丁云录;李驰坤;李晓兵;初洪波;成光宇;
摘要(Abstract):
目的探讨清肝降浊颗粒对非酒精性脂肪性肝病(NAFLD)模型大鼠肝脏的保护作用及其机制。方法将Wistar大鼠随机分为正常组、模型组、清肝降浊颗粒高、中和低剂量组(800、400和200 mg/kg),用高脂饲料喂养12周制备非酒精性脂肪性肝病模型,造模同时灌胃给药,每日1次。给药周期结束,检测血清TNF-α、IL-6、ADPN、Lep质量浓度及肝组织中FFA和TG摩尔浓度。结果造模成功后,模型组大鼠血清TNF-α、IL-6、Lep、肝组织中FFA和TG质量浓度明显升高;血清脂联素质量浓度明显降低,与正常对照组比较,均为P <0.01。在给予清肝降浊颗粒颗粒药物干预后,与模型组比较,清肝降浊颗粒高、中、低3个剂量组均可显著降低肝组织匀浆中TG摩尔浓度及升高血清中脂联素质量浓度(P <0.01或P <0.05);清肝降浊颗粒高、中2个剂量组均可显著降低肝组织匀浆中FFA摩尔浓度及血清中TNF-α、Lep质量浓度(P <0.01或P <0.05);清肝降浊颗粒高剂量组可显著降低血清中IL-6质量浓度(P <0.05)。结论清肝降浊颗粒改善非酒精性脂肪性肝病的作用机制,与降低血清TNF-α、IL-6、Lep质量浓度、肝组织FFA摩尔浓度,升高血清脂联素质量浓度相关。
关键词(KeyWords): 清肝降浊颗粒;非酒精性脂肪性肝病;炎症因子;大鼠
基金项目(Foundation): 吉林省中医药科技项目(2017182)
作者(Author): 王胜军;丁云录;李驰坤;李晓兵;初洪波;成光宇;
Email:
DOI: 10.13463/j.cnki.jlzyy.2019.06.023
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