清肺固本汤治疗慢性阻塞性肺疾病稳定期80例临床研究Clinical Research on 80 Cases of Chronic Obstructive Pulmonary Disease in Stable Stage Treated by Qingfei Guben Decoction
蔡绪明;王志梅;杨栓柱;孙昉昉;张军城;王文;
摘要(Abstract):
目的评价清肺固本汤治疗慢性阻塞性肺疾病(COPD)稳定期的临床疗效。方法回顾分析80例COPD稳定期患者,采用随机数字表法分为治疗组、对照组,各纳入40例病例,对照组应用沙美特罗替卡松粉吸入剂(50μg/500μg)治疗,治疗组患者在对照组基础上加用清肺固本汤(枳壳10 g,桔梗10 g,陈皮10 g,法半夏9 g,茯苓15 g,桑白皮15 g,杏仁10 g,黄芩10 g,浙贝母15 g,乌贼骨15 g,苏子10 g,莱菔子15 g,炒冬瓜仁15 g,太子参15 g,炒白术10 g,炒麦芽30 g等),每月为1疗程,连续用药3个疗程。结果评价结果显示,治疗组总有效率(92.50%)显著高于对照组(75.00%)(P <0.05)。与治疗前比较,2组治疗后患者单项症状咳嗽、咳痰、气喘、呼吸困难指数、肺功能均有显著差异(P <0.05);2组治疗后组间对比,治疗组患者单项症状咳嗽、咳痰、呼吸困难指数分别为(1.55±1.47)分、(1.45±0.91)分、(1.20±0.76)分、均明显低于对照组(P <0.05),急性加重风险低于对照组(P <0.05),肺功能变化差异无统计学意义(P> 0.05)。结论在COPD稳定期,清肺固本汤可能通过改善血管内皮功能障碍,减轻气道炎症反应,从而改善患者咳嗽、咳痰等症状,提高总有效率,并降低急性加重风险。
关键词(KeyWords): 慢性阻塞性肺疾病;清肺固本汤;沙美特罗替卡松粉吸入剂
基金项目(Foundation): 陕西省中医管理局中医药科研课题(2017ZYPT016)
作者(Author): 蔡绪明;王志梅;杨栓柱;孙昉昉;张军城;王文;
Email:
DOI: 10.13463/j.cnki.jlzyy.2019.12.021
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