罗利琼;胡林;王继红;霍丹;张小丽;张高;马玉芳;

• 1:武汉科技大学附属天佑医院肿瘤科

摘要(Abstract)：

目的观察加味参麦汤在中晚期食管癌三维适形放疗治疗中的减毒增效作用。方法将63例中晚期食管癌患者随机分为3组,各21例,均采用三维适形放射治疗,放疗对照组(A组)口服配制液,参麦注射液组(B组)予参麦注射液静脉滴注(1次/d),加味参麦汤联合放疗组(C组)同时口服加味参麦汤(50 mL,2次/d),至放疗结束。结果 C组临床获益率高于A组和B组,差异有统计学意义(P<0.05);在生存质量和症状缓解评价方面,C组优于A组和B组(P<0.05);TGF-β1和IL-6在放疗后3组结果无统计学差异(P>0.05)。结论加味参麦汤对中晚期食管癌患者三维适形放疗治疗没有增效的作用;对早期急性放射反应起到一定的减毒作用,但不是通过影响细胞因子TGF-β1和IL-6水平实现的。

关键词(KeyWords)： 加味参麦汤;食管肿瘤;放射疗法;三维适形

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 罗利琼;胡林;王继红;霍丹;张小丽;张高;马玉芳;

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参考文献(References)：

• [1]Hurmuzlu M,Monge OR,Smaaland R,et al.High-dose definitive concomitant chemoradiotherapy in non-metastatic locally advanced esophageal cancer:toxicity and outcome[J].Dis Esophagus,2010,23(3):244-252.
• [2]Sakayauchi T,Nemoto K,Ishioka C,et al.Comparison of cisplatin and 5-fluorouracil chemotherapy protocols combined with concurrent radiotherapy for esophageal cancer[J].Jpn J Radiol,2009,27(3):131-137.
• [3]LUJun-zhang,ZHAO Hong,LIU Yi,et al.Clinical study on preventionandtreatmentforacuteradiation esophagitis by Modified Lophatheri and Gypsi Fibrosi Decoction[J].China Journal of TCM and Pharmacy,2010,25(1):59-62.
• [4]XULi-chun,ZOUCai-liang.Effect of modified Qigesan preventing radioactive esophagitis[J].Journal of Emergency in TCM,2010,19(6):929.
• [5]王洪鹏,李晓君.食管癌的中西医治疗研究进展[J].吉林中医药,2013,33(4):428-429.
• [6]朱海涛,袁成业.食管癌及其术后吻合口炎的中医治疗[J].吉林中医药,2013,33(5):471-473.
• [7]路军,张蕾.中医药防治急性放射性食管炎[J].中华中医药杂志,2012,27(12):3019-3022.
• [8]余健,辛艳飞,宣尧仙.参麦注射液药理作用的物质基础研究进展[J].医药导报,2013,32(4):497-500.
• [9]参文彩虹,冯晓庆,罗荣城.麦注射液联合TP方案同步放疗治疗中晚期宫颈癌的临床观察[J].中国药房,2012,23(8):702-704.
• [10]Hirota S,Tsujino K,Endo M,et al.Dosimetric predictors of radiation esophagitis in patients treated fornon-small-cell lung cancer with carboplatin/paclitaxel/radiotherapy[J].Int J Radiat Oncol Biol Phys,2001,51(2):291-295.
• [11]孙燕,周际昌.临床肿瘤内科手册[M].北京:人民卫生出版社,2003:159-160.
• [12]Bedford JL,Viviers L,Guzei Z,et al.A quantitative treatment planning study evaluating the potential of dose escalation in conformal radiotherapy of the oesophagus[J].Radiother Oncol,2000,57(2):183-193.
• [13]Yang GY,McClosky SA,Khushalani NI.Principles of modern radiation techniques for esophageal and gastroesophageal junction cancers[J].Gastrointest Cancer Res,2009,3(2):6-10.
• [14]Wang J,Qiao XY,Lu FH,et al.TGF-beta1 in serum and induced sputum for predicting radiation pneumonitis in patients with nonsmall cell lung cancer after radiotherapy[J].Chin J Cancer,2010,29(3):325-329.
• [15]Rǜbe CE,Palm J,ErrenM,et al.Cytokine plasma levels:reliable predictors for radiation pneumonitis[J].P Lo S One,2008,3(8):2898.