逍遥散防治肝纤维化的实验研究
朱光泽,刘铁梅,张秀华
摘要(Abstract)：
<正> 逍遥散(mixture Xiao Yao Shan,MXYS)是我国民间传统的药方,在治疗实验性特异性脂蛋白诱发的自身免疫性肝炎过程中,笔者在经方中加入枸杞子,经多家临床试用有较好的疗效。为了进一步探讨该方剂抗肝纤维化的作用机理,进行了此项研究。1 材料与方法1.1 药品与试剂MXYS 由柴胡、当归、白芍、白术、茯苓、甘草6味中药组成,笔者在此基础上加入枸杞子,按一定比例组方在长春中医学院附属医院制剂室
关键词(KeyWords)： 肝纤维化;逍遥散;实验研究
基金项目(Foundation):
作者(Author): 朱光泽,刘铁梅,张秀华
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参考文献(References)：
- [1] Guarner C,Soriawo G,Tomas A,et al.Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia. Hepateology, l993, 18(5) : 1139
- [2] . Stuchr DJ,Marletta MA, Mammalian. Nitrite biosynthesis:mouse macrophages produce nitrite and nitrate in response to Escherichia Coli lipopolysaccharide.Pore Natl Aci USA, 1985, 82:7738．
- [3] 钱绍诚.肝纤维化(肝硬化)的可逆性[J].中华消化杂志,1995,15(5) :251
- [4] 黄自平,郭冰,梁扩寰.当归对肝硬化门脉高压患者全身及门脉血液动力学的影响[J].中华内科杂志,1996,35(1) :15
- [5] Peterson TC, Ibrucker RA.Fibroproliferatin in liver disease: Role of monocyte factors. Wepatology, 1992, 15(2) : 191
- [6] Yoshioka R, KakumuS, Arao M, et al.Tumor necrosis factor-a production by peripheral blood mononuclear cells of patients with chronic liver disease Hepatology, 1989, 10(5) :769
- [7] Andus T, Bauner J,Gerok W.Effects of cytokines on the liver. Hepatology, 1991, 13(2) : 364．