舒肝健脾颗粒对溃疡性结肠炎大鼠模型VIP和IL-10水平的影响
秦震声;王轶;赵耀;王艳逊;钟馨;杜炳林;
摘要(Abstract)：
目的:探讨舒肝健脾颗粒对溃疡性结肠炎肝郁脾虚模型大鼠的治疗作用及作用机制。方法:采用TNBS/乙醇溶液灌肠加束缚法制作溃疡性结肠炎(UC)肝郁脾虚大鼠模型,观察舒肝健脾颗粒对大鼠局部结肠血管活性肠肽(VIP)和白介素-10(IL-10)水平的影响。结果:舒肝健脾颗粒可以有效对抗肝郁脾虚模型大鼠结肠组织中的IL-10水平的降低(P<0.05,P<0.01),并升高组织中VIP含量(P<0.05,P<0.01)。结论:舒肝健脾颗粒可以调节肝郁脾虚模型大鼠结肠组织中的VIP浓度,并可以抑制局部炎症反应。
关键词(KeyWords)： 舒肝健脾颗粒;血管活性肠肽;白介素;溃疡性结肠炎
基金项目(Foundation):
作者(Author): 秦震声;王轶;赵耀;王艳逊;钟馨;杜炳林;
Email:
DOI: 10.13463/j.cnki.jlzyy.2007.03.040
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