调心方治疗老年性痴呆机理研究
蔡秋芳;
摘要(Abstract):
随着我国老龄化的日益突出,阿尔茨海默病(Alzheimer’s Disease,AD)发病率呈逐年上升趋势,AD将成为我国社会学及医学领域急待攻克的难关。中药以其多作用靶点,低毒性的优点,在AD的治疗中具有独特优势。
关键词(KeyWords): 阿尔茨海默病;痴呆;调心方
基金项目(Foundation):
作者(Author): 蔡秋芳;
Email:
DOI: 10.13463/j.cnki.jlzyy.2008.03.028
参考文献(References):
- [1]邱宏,金国琴,赵伟康,等.调心方对氧化损伤型类AD大鼠空间记忆能力和脑线粒体呼吸功能的影响[J].中国中医基础医学杂志,2006,8(6):26-29.
- [2]姚明忠,赵伟康.调心方对淀粉样蛋白所致大鼠海马神经元凋亡的调控作用[J].中草药,2001,32(6):521-524.
- [3]Carson K A,Geula C,Mesulam M M.Electron microscopic local-ization of cholinesterase activity in A lzheimer,s brain tissue[J].Brain Res,1991,540:204.
- [4]叶挺梅.从神经生理谈老年性痴呆症的发病机制与疗法[J].丽水学院学报,2006,28(5):62-64.
- [5]Zhao W K.Effects of traditional Chinese medical Heart-ben-efitting and Kidney-tonifying on adrenergic nervous system of the“dementia”and dysmnesia rat model[J].Chin J Inte-gratedTradit Chin West Med,1993,(Collection of Basal Theses):20-21.
- [6]孙泉,金国琴,赵伟康,等.调心方对AD大鼠脑组织抗氧化能力的影响[J].中国中医药科技,2003,10(5):273-274.
- [7]诸秉根,陈宜张.神经系统内高亲和谷氨酸摄取及调节影响因素[J].生理科学进展,1997,28(4):295.
- [8]林晓明,冯建英,龙珠,等.银耳、茯苓、绞股蓝对小鼠免疫功能和清除自由基的作用[J].首都医科大学学报,2006,27(6):455-457.
- [9]雷云玲,王新惠,李再新.Caspasess介导老年性痴呆发病机制的研究[J],2006,19(6):62-65.
- [10]Guo H,Albrecht S,Bourdeau M,et al.Active caspases-6 andcaspases-6-cleaved tau in neutropil threads,neuriticplaques,and neurofibrillary tangles of Alzheimer’s disease[J].Am J Pathol,2004,165:523-531.
- [11]Raf M C,Barres B A,Burne J F,et al.Jacobson MD:Pro-grammed cell death and the control of cell survival:lessons fromthe nervous system[J].Science,1993,262:695-700.
- [12]孟艳,王蓉,刘梦霞,等.阿尔茨海默病患者神经元凋亡机制中相关因素的研究[J].中华老年医学杂志,2006,26(4):245-247.
- [13]Riley K P,Snowdon D A,Markesberyw R.Alzheimers’neurofi-brillary pathology and the spectrum of cognitive function:findingsfrom the nun study[J].Ann Neuro,l,2002,51(5):567-577.
- [14]Gong C X,Liu F,Grundke-Iqbal I,et al.Post-translation-almodifications of tau protein in alzheimers’disease[J].JneuralTransm,2005,112:813-838.
- [15]刘学源,赵伟康,徐品初,等.调心方对杏仁核注射Aβ25-35诱导的阿尔茨海默病模型大鼠的影响[J].中草药,2004,35(1):50-53.
- [16]Rapoportm,Dawsonh N,Binder L I,et al.Tau is es-sential tobeta-amyloid-induced neurotoxicity[J].Proc NatlAcad Sci-USA,2002,99:6364-6369.
- [17]Liu F,Grundke-Iqbal I,Iqbal K,et al.Contributions of proteinphosphatasespp1,pp2a,pp2b and pp5 to the regulation of tauphosphorylation[J].Eur JNeurosc,i,2005,22:1942-1950.