锦红汤对脓毒症大鼠血清炎症因子的影响Effect of serum inflammatory factors on rats with sepsis by Jinhong decoction
李炯;叶圳;顾宏刚;蔡滨;
摘要(Abstract)：
目的研究锦红汤对脓毒症大鼠血清炎症因子(CRP、IL-6、IL-8、TNF-α)的影响。方法本实验分为正常组、假手术组、模型组、西药组、中药组、联合组6组,各治疗组在造模基础上给予相应药物处理,包括锦红汤(大黄、红藤、蒲公英)灌胃、亚胺培南180 mg/(kg·d)腹腔内注射、及联合用药,按造模后0、2、6、24 h取材,观察6组大鼠血清炎症因子(CRP、IL-6、IL-8、TNF-α)的变化。结果在观察时间内,模型组、中药组、西药组、联合组在造模后CRP、IL-6、IL-8、TNF-α浓度均出现了上升趋势,在模型组持续维持在高位,各治疗组在24 h时均明显低于模型组。结论中药锦红汤可显著抑制炎症因子(CRP、IL-6、IL-8、TNF-α)。
关键词(KeyWords)： 脓毒症;白介素;肿瘤坏死因子;锦红汤;大鼠
基金项目(Foundation): 上海市自然科学基金(15ZR1441800);; 上海市龙华医院科技创新课题(KY1762)
作者(Author): 李炯;叶圳;顾宏刚;蔡滨;
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DOI:
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