于一江;洪兵;陈丽娟;殷学超;

• 1:淮安市中医院内分泌科

摘要(Abstract)：

目的观察桃红四物汤对2型糖尿病阴虚血瘀证患者心肌病变及氧化应激指标(SOD、GSH-Px以及MDA)的影响。方法选择60例本院2型糖尿病阴虚血瘀证住院患者,按照就诊顺序,将其分为对照组和观察组,每组30例。2组患者均进行生活方式干预及常规降糖药物治疗;对照组服用曲美他嗪(20 mg,3次/d),观察组在对照组基础上,加用桃红四物汤治疗,每日1剂,煎汤400 m L,2次/d。2组均以4周为1疗程,共治疗5个疗程。观察并比较临床疗效及治疗前后FBG、Hb Alc、氧化应激指标(SOD、GSH-Px以及MDA)血清水平的变化。结果 2组治疗后20周后随访临床疗效比较显示:观察组有效率显著高于常规治疗组,差异有统计学意义(P<0.01)。治疗后2组FBG、Hb Alc均明显降低(P<0.05);与对照组治疗后比较,观察组FBG、Hb Alc降低更加明显(P<0.05)。与治疗前比较,对照组治疗后血清SOD、GSH-Px以及MDA水平差异无统计学意义(P>0.05);与治疗前比较,观察组治疗后血清SOD、GSH-Px水平明显升高,血清MDA水平明显降低(P<0.05);与对照组治疗后比较,观察组治疗后血清SOD、GSH-Px水平明显升高,血清MDA水平明显降低(P<0.05)。结论桃红四物汤联合曲美他嗪治疗可以显著改善糖尿病阴虚血瘀证的临床表现和心电图变化,其机制除了与血糖控制有关外,还可能与显著抑制氧化应激反应有关。

关键词(KeyWords)： 2型糖尿病;阴虚血瘀证;心肌病变;氧化应激;桃红四物汤

Abstract:

Keywords:

基金项目(Foundation): 淮安市科技计划科学基金(HASZ2012017)

作者(Author): 于一江;洪兵;陈丽娟;殷学超;

Email:

DOI: 10.13463/j.cnki.jlzyy.2016.02.008

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