冯月男;孙思邈;牛雯颖;张玉昆;卞敬琦;肖洪彬;

• 1:黑龙江中医药大学

摘要(Abstract)：

外泌体是一种具有双分子磷脂结构,直径为30～100μm的囊状小泡,表面含有DNA、RNA、蛋白质、脂质等多种生物活性物质,可以远距离传递生物信息,因此被称为"天然药物载体",在心血管领域具有重要价值。传统中医药在治疗心血管疾病方面虽具有完整的理论体系和良好的临床疗效,但因其有效成分溶解度低、生物利用度不高,治疗过程长,见效慢等缺点,限制了药物充分利用。而利用外泌体这种新型药物载体,能使药物的有效成分直接递送至靶细胞,更好、更快的发挥药物的作用。本文就外泌体的生物学特征、功能特点及其作为中药载体的研究进展进行综述。

关键词(KeyWords)： 外泌体;心血管疾病;中药;载体

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81473555,81703981);; 黑龙江省博士后科研启动金资助项目(LBH-Q16213);; 黑龙江省自然科学基金面上项目(H2015023);; 黑龙江省博士后资助项目(LBH-Z18250);; 黑龙江省普通本科高等学校青年创新人才培养计划(UNPYSCT-2016077,UNPYSCT-2018232);; 黑龙江省高校基本科研业务费支持计划项目(2017PT07);; 黑龙江中医药大学科研基金项目(201739)

作者(Author): 冯月男;孙思邈;牛雯颖;张玉昆;卞敬琦;肖洪彬;

Email:

DOI: 10.13463/j.cnki.jlzyy.2019.06.036

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