徐炎;孔一卜;杨福双;王中天;姚博;孙丽平;

• 1:长春中医药大学
• 2:长春中医药大学附属医院

摘要(Abstract)：

肺炎链球菌是世界范围内引起社区获得性肺炎的主要原因,抗生素耐药严重阻碍了人类治疗肺炎链球菌性疾病的能力,因此寻找新的抑菌方法极其重要。天然产物已成为治疗重大疾病的药物或其先导物的主要来源。本文总结了近5年天然产物抑制肺炎链球菌的报道,包括天然产物直接抑菌的MIC、MBC、IZD,抑制肺炎链球菌毒力因子,与抗生素联用协同增效,抑制群体感应及与纳米技术结合等。探讨了在"抗生素后时代"应用疫苗、益生菌、噬菌体、抗菌肽治疗肺炎链球菌疾病的优缺点。认为天然产物的研发会为解决抗生素耐药这一全球问题提供思路与方法。

关键词(KeyWords)： 肺炎链球菌;抗生素耐药;天然化合物

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(2017YFC1703202);; 吉林省卫生计生委科技项目(2018J106);; 吉林省卫生系统拔尖创新人才工程项目(2011);; 长春中医药大学重点学科提升计划项目(〔2019〕18号);; 中医药传承与创新“百千万”人才工程(岐黄工程)王烈国医大师传承工作室项目

作者(Author): 徐炎;孔一卜;杨福双;王中天;姚博;孙丽平;

Email:

DOI: 10.13463/j.cnki.jlzyy.2020.07.009

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