中药有效成份对脂肪细胞功能的影响
赵晓华;尚文斌;
摘要(Abstract)：
脂肪组织在机体的能量代谢中发挥着重要的调控作用,脂肪细胞的糖脂代谢功能紊乱和分化异常可诱发糖尿病及相关疾病的发生、发展。近年来国内外研究者针对中药有效成份对脂肪细胞的作用及其机制影响做了一系列分子水平的研究工作,这些成果将有助于深入了解中医药抗糖尿病作用的机制,提供中医药防治糖尿病及其相关疾病的科学实验依据和临床运用指导。
关键词(KeyWords)： 脂肪细胞;小檗碱;人参皂苷;大黄素;黄芪多糖
基金项目(Foundation):
作者(Author): 赵晓华;尚文斌;
Email:
DOI:
参考文献(References)：
- [1]周丽斌,陈名道,宋怀东.小檗碱对脂肪细胞葡萄糖转运的影响及其机制研究[J].中华内分泌代谢杂志,2003,19(6):479-482.
- [2]周丽斌,陈名道,王晓,等.小檗碱对脂肪细胞分化的影响[J].中华医学杂志,2003,83(4):338-340.
- [3]Lee YS,Kim WS,Kim KH,et al.Berberine,a natural plant prod-uct,activates AMP-activated protein kinase with beneficial meta-bolic effects in diabetic and insulin-resistant states[J].Diabetes,2006,55(8):2256-2265.
- [4]Cheng Z,Pang T,Gu M,et al.Berberine-stimulated glucose up-take in L6 myotubes involves both AMPK and p38 MAPK[J].Bio-chimica et Biophysica Acta,2006,1760:1682-1689.
- [5]Huang C,Zhang YB,Gong ZW,et al.Berberine inhibits 3T3-L1adipocyte differentiation through the PPAR pathway[J].Biochemi-cal and Biophysical Research Communications,2006,348:571-578.
- [6]Shang WB,Yang Y,Jiang BR,et al.Ginsenoside Rb1 promotesadipogenesis in 3T3-L1 cells by enhancing PPARγ2 and C/EBPαgene expression[J].Life Sciences,2007,80:618-625.
- [7]Park MY,Lee KS,Sung MK.Effects of dietary mulberry,Koreanred ginseng,and banaba on glucose homeostasis in relation toPPARα,PPARγand LPL mRNA expressions[J].Life Sciences,2005,77:3344-3354.
- [8]Wang H,Reaves LA,Edens NK.Ginseng extract inhibits lipolysisin rat adipocytes in vitro by activating phosphodiesterase 4[J].JNutrition,2006,136:337-342.
- [9]Han KL,Jung MH,Sohn JH,et al.Ginsenoside 20(S)-proto-panaxatriol(PPT)activates peroxisome proliferators-activatedreceptorγ(PPARγ)in 3T3-L1 adipocytes[J].Biol Pharm Bull,2006,29:110-113.
- [10]张崇本,滕路,时艳,等.大黄素对3T3-L1前脂肪细胞增殖分化及脂肪代谢的影响[J].中国医药杂志,2002,115(7):1101-1117.
- [11]杨永青,杨公社.大黄素对大鼠前体脂肪细胞增殖与分化的影响[J].中国中药杂志,2007,32(5):424-427.
- [12]Yang Y,Shang WB,Zhou LB,et al.Emodin with PPAR ligand-binding activity promotes adipocyte differentiation and increas-es glucose uptake in 3T3-Ll cells.[J].Biochemical and Bio-physical Research Communications,2007,353:225-230.
- [13]王树海,王文健,汪雪峰,等.黄芪多糖和小檗碱对3T3-L1脂肪细胞糖代谢及细胞分化的影响[J].中国中西医结合杂志,2004,24(10):926-928.
- [14]刘毅,王文健,陈伟华,等.黄芪多糖对3T3-L1前脂肪细胞增殖和分化的影响[J].中西医结合学报,2007,7(4):421-426.