尹红章;万淑琼;

• 1:黄石中心医院妇产科

摘要(Abstract)：

目的观察中药调经汤对多囊卵巢综合征不孕(PCOS)的治疗效果,并探究其作用机制。方法患者共86例,并随机分为观察组和对照组各43例。对照组采用基础治疗方法:服用决雌醇环丙孕酮片和枸橼酸氯米芬,并注射用尿促性素(疗程为3个月经周期)。观察组在采用基础治疗的基础上加以调经汤治疗(疗程为3个月经周期)。用B超监测卵泡的发育情况,测定主导卵泡膜血流,并对搏动指数(PI)和阻力指数(RI)做好记录;分别监测并对比患者治疗前后的空腹血糖(FBG)水平、瘦素(PI)水平和空腹胰岛素(FINS)水平,计算胰岛素抵抗指数(HOMA-R);监测并记录人绒毛膜促性腺激素(HCG)水平(注射日)、黄体生成素(LH)水平、雌二醇(E2)水平、血清睾酮(T)水平以及卵泡刺激素(FSH)水平;对治疗后患者月经恢复率、排卵率以及妊娠率做好记录。结果 2组患者治疗后,观察组月经恢复率(93.02%),排卵率(86.04%)和妊娠率(72.09%)均比对照组月经恢复率(69.77%)、排卵率(55.81%)和妊娠率(39.53%)高,差异具有统计学意义(P<0.01);PI均较治疗前显著升高,且观察组比对照组高,差异具有统计学意义(P<0.01);RI比治疗前有较明显降低,且观察组比对照组低,差异具有统计学意义(P<0.001);观察组FSH水平,LH水平和E2水平相较于对照组均有显著提高,T水平比对照组低,差异均具有统计学意义(均P<0.001);2组FINS水平、IR水平和LP水平相较于治疗前均有明显降低,且观察组比对照组低,差异具有统计学意义(P<0.001)。结论基础治疗加上调经汤共同治疗,对患者卵巢血流、高雄激素血症、胰岛素抵抗质量起改善作用,提高卵泡质量,继而对排卵率和妊娠率起到显著的提高作用。

关键词(KeyWords)： 调经汤;多囊卵巢综合征;妊娠率;月经恢复率;卵泡质量

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 尹红章;万淑琼;

Email:

DOI: 10.13463/j.cnki.jlzyy.2016.07.014

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