张向磊;胡冬青;孙欢娜;李勇;

• 1:山东中医药大学第一临床医学院
• 2:山东中医药大学附属医院

摘要(Abstract)：

目的探讨护肠清毒微丸结肠靶向给药降低血浆内毒素及TNF-α、IL-6、IL-8的疗效。方法符合纳入标准的慢乙肝相关肠源性内毒素血症患者180例,按随机双盲双模拟对照分为口服乳果糖组、口服护肠清毒微丸组,每组各90例,观察治疗前后血浆内毒素及TNF-α、IL-6、IL-8变化,并比较2种药物的疗效差别。结果2组血浆内毒素、炎性细胞因子较治疗前均明显下降(P<0.01),且护肠清毒微丸疗效优于乳果糖组(P<0.01)。结论护肠清毒微丸结肠靶向释放给药可有效阻断肠源性内毒素血症的发生,改善机体内环境,从而抑制炎性细胞因子的释放,达到修复肝组织损伤的目的,整体疗效优于乳果糖。

关键词(KeyWords)： 护肠解毒微丸;肠源性内毒素血症;乳果糖;利湿解毒;活血化瘀

Abstract:

Keywords:

基金项目(Foundation): 国家中医临床研究基地业务建设科研专项(JDZX2012065);; 山东省科技厅科技攻关课题(2007GG2NS02076)

作者(Author): 张向磊;胡冬青;孙欢娜;李勇;

Email:

DOI: 10.13463/j.cnki.jlzyy.2016.09.008

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