B型利钠肽与慢性心力衰竭患者中医证型及预后的关系
庞建中;齐新;刘克强;刘玥;
摘要(Abstract)：
目的:研究B型利钠肽(NT-proBNP)水平与慢性心力衰竭(CHF)患者中医证型及其预后的关系。方法:入选CHF患者64例,健康人20例作为对照组。按NYHA分级进行评估,并将患者分为气阴两虚证、气虚血瘀证及心肾阳虚证3种证型。用ELISA染色法测血清NT-proBNP水平。结果:慢性心力衰竭患者3组中医证型组NT-proBNP的水平不同,心肾阳虚证组高于气虚血瘀证和气阴两虚证,差异有统计学意以(P<0.01)。发生终点事件组(心源性死亡,因心功能恶化、急性冠脉综合症、心律失常再入院)NT-proBNP明显高于未发生终点事件组,其中死亡组的NT-proBNP较再入院组升高,各组比较有统计学意义(P<0.01)。结论:血清标记物NT-proBNP对患者的预后具有一定的预测价值,并可作为心力衰竭中医辨证分型的客观化指标之一。
关键词(KeyWords)： 心力衰竭;NYHA分级;B型利钠肽;中医证型
基金项目(Foundation):
作者(Author): 庞建中;齐新;刘克强;刘玥;
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参考文献(References)：
- [1]Sharon A,Hunt DW,Baker MH,et al.ACC/AHA Guidelines forthe Evaluationand Management of Chronic Heart Failure in theAdult:Executive Summary A Report of the American College ofCardiology/American Heart Association Task Force on PracticeGuidelines(Committee on Management of Patients with ValvularHeart Disease)[J].Circulation,2007,104(24):2996-3007.
- [2]Hunt SA,Baker DW,Chim MH,et al.ACC/A IIA guidelines forthe evaluation and mananement of chronic heart failure in theadult[J].Circulation,2001,104(24):2996-3007.
- [3]SudohT,KangawaK,Minamino N,et al.A new natriuretic peptidein porcine brain[J].Nature,1988,322(6159):78-81.
- [4]Tsuruda T,Boerrigter G,HuntleyBK,et al.Brain natr-i uretic peptide is p-roduced in cardiac fibroblasts and induces matrixmetalloproteinases[J].Circ Res,2002,91:1127-1134.
- [5]Ruskoaho H.Cardiac hormones as diagnostic tools in heart failure[J].Endocr Rev,2003,24(3):341-356.
- [6]Dessi Fulgheri P,Sarzani R.Rappelli a role ofthe natriuretic pep-tidesystem in lipogenesis/lipolysis[J].Nutr Metab CardiovascDis,2003,13(4):2249.
- [7]Wieczorek SJ,Wu AH,Christens R,et al.A rapid B-type natr-iureticpeptide assay accurately diagnses left ventricular dysfunctionand heart failurea multicenter evaluation[J].Am Heart J,2002,144(5):834.
- [8]李健,何怀阳,林晓忠.BNP在心衰中医辨证分型中的应用[J].辽宁中医杂志,2005,32(9):879.