中西结合治疗小儿抗生素相关性腹泻Combination of Chinese and Western Medicine in the Antibiotic Associated Diarrhea of Children
阮小东;
摘要(Abstract):
目的分析探讨中西医结合治疗小儿抗生素相关性腹泻患儿hs-CRP、IL-8、IL-12及TNF-α的影响。方法选取我院于2015年8月-2018年8月收治的114例小儿抗生素相关性腹泻患儿,按照随机数字表法分为对照组和研究组,各57例。所有患儿均给予酪酸梭活菌散进行治疗,研究组在此基础上联合使用小儿腹泻散进行治疗,2组均持续治疗2周。记录2组恶心、呕吐、腹泻、发热等症状缓解时间,分析2组外周血超敏C反应蛋白水平、TNF-α、IL-8、IL-12等指标,比较2组不良反应发生率。结果研究组总有效率为94.74%,显著高于对照组的82.46%(P <0.05)。研究组腹泻缓解时间和发热、恶心、呕吐等缓解时间均显著低于对照组(均P <0.05)。治疗后,2组hs-CRP、TNF-α、IL-8、IL-12等炎症因子水平均显著优于本组治疗前(均P <0.05),且研究组显著优于同期对照组(均P <0.05)。2组患儿在治疗期间均未出现有严重不良反应情况。结论对小儿抗生素相关性腹泻患儿采用中西医结合治疗,能够有效改善hs-CRP、TNF-α、IL-8、IL-12等指标,治疗效果显著,不良反应发生率低,值得在临床上推广运用。
关键词(KeyWords): 腹泻;中西医结合;抗生素;儿童;超敏C反应蛋白
基金项目(Foundation): 湖北省卫计委指导性项目(WJ2016F207)
作者(Author): 阮小东;
Email:
DOI: 10.13463/j.cnki.jlzyy.2019.09.023
参考文献(References):
- [1]ARIEIRA C,DE CASTRO F D,MOREIRA M J,et al.Common Variable Immunodeficiency-Associated Inflammatory Enteropathy:The New Era of Biological Therapy[J].GE Port J Gastroenterol,2018,25(6):322-326.
- [2]MARTIN-CASTILLO B,PERNAS S,DORCA J,et al.Aphase 2 trial of neoadjuvant metformin in combination with trastuzumab and chemotherapy in women with early HER2-positive breast cancer:the METTEN study[J].Oncotarget,2018,9(86):35687-35704.
- [3]白进,黄彩虹,张斌.小儿腹泻散联合酪酸梭菌活菌散对抗生素相关性腹泻患儿hs-CRP、IL-8、IL-12及TNF-α的影响[J].陕西中医,2017,38(7):837-838.
- [4]任晓颖,周天羽.李中梓治泄9法在溃疡性结肠炎中运用[J].长春中医药大学学报,2018,34(3):466-469.
- [5]HUANG Z H,MA X W,ZHANG J,et al.Cetuximab for esophageal cancer:an updated meta-analysis of randomized controlled trials[J].BMC Cancer,2018,18(1):1170.
- [6]张永政,王海.健脾止泻汤治疗小儿腹泻[J].吉林中医药,2017,37(1):52-54.
- [7]GUTIERREZ-CAMINOá,UMEREZ M,LOPEZ-LOPEZE,et al.Involvement of miRNA polymorphism in mucositis development in childhood acute lymphoblastic leukemia treatment[J].Pharmacogenomics,2018,19(18):1403-1412.
- [8]ZHAO T T,CUI L,LI J J,et al.Optimal expression and purification of sapelovirus A structural protein VP1,and its immunogenicity in mice[J].Pol J Vet Sci,2018,21(3):573-579.
- [9]孙小叶,王静.吴茱萸散敷脐联合足底穴位按摩治疗腹泻患儿[J].吉林中医药,2016,36(10):1059-1062.
- [10]FABISIAK M,SA?AMASZY?SKA A,STADEJEK T.Detection of seroconversion to bovine herpesvirus 1 related alphaherpesvirus and bovine viral diarrhea virusin Polish free-living deer[J].Pol J Vet Sci,2018,21(3):437-440.