施嫣嫣;张丽;丁安伟;

• 1:南京中医药大学江苏省方剂研究重点实验室

摘要(Abstract)：

墨旱莲具有多种化学成分,如三萜皂苷类、黄酮类、噻吩类及香豆草醚类等,现代药理学研究表明,墨旱莲具有止血、保肝、免疫调节、抗肿瘤、抗炎、降血脂、抗缺氧、抗蛇毒等生物及药理作用。

关键词(KeyWords)： 墨旱莲;化学成分;药理活性

Abstract:

Keywords:

基金项目(Foundation): 江苏省中医药管理局研究项目支撑(编号:LB09031)

作者(Author): 施嫣嫣;张丽;丁安伟;

Email:

DOI: 10.13463/j.cnki.jlzyy.2011.01.036

参考文献(References)：

• [1]国家药典委员会.中华人民共和国药典[M].北京:化学工业出版社,2005:2591.
• [2]袁继承,蒋永和,沈志滨.旱莲草化学成分的研究进展[J].亚太传统医药,2009,1(5):125-127.
• [3]SUNZhi-Hua,ZHANG Chao-Feng,ZHANG Mian.ANewBenzoicAcid Derivative fromEclipta prostrata[J].Chinese Journal of Nat-ural Medicines,2010,8(4):0244-0246.
• [4]营大礼.墨旱莲化学成分、药理作用及临床应用研究进展[J].中国药房,2008,19(26):2876-2877.
• [5]刘翔,曹云飞,窦金凤.不同产地墨旱莲中木樨草素含量测定[J].中国药业,2007,16(23):12-13.
• [6]Mi Kyeong Lee,Na Ry Ha,Hyekyung.Stimulatory Constituents ofEclipata prostrata on Mouse Osteoblast Differentiation[J].WileyInterScience,2009,6(23):129-131.
• [7]原红霞,赵云丽,王晓英,等.反相高效液相色谱法同时测定墨旱莲中的蟛蜞菊内酯和异去甲基蟛蜞菊内酯[J].色谱,2007,25(3):371-373.
• [8]吴疆,侯文彬,张铁军,等.墨旱莲的化学成分研究[J].中草药,2008,39(6):814-816.
• [9]Supinya Tewtrakul,Sanan Subhadhirasakul,Sarot Cheenpracha.HIV-1 Protease and HIV-1 Integrase Inhibitory Substances fromEclipta prostrata[J].Wiley InterScience,2007,15(21):1092-1095.
• [10]陈献,王艳红.墨旱莲的化学成分与药理作用研究进展[J].广西中医院学报,2008,11(1):76-77.
• [11]庄晓燕,杨菁,李华侃,等.热盛胃出血小鼠模型的制作及墨旱莲对其止血作用机制的研究[J].数理医学杂志,2010,23(1):31-32.
• [12]刘世旺,徐艳霞,徐霞玲,等.墨旱莲叶水提取物止血活性初探[J].安徽农业科学,2008,36(31):13673-13674.
• [13]申芳超.二至丸合左归丸治疗青春期崩漏53例疗效观察[J].吉林中医药,2008,28(1):39.
• [14]Mi Kyeong Lee,Na Ry Ha,Hyekyung Yang,et al.Antiprolifera-tive activity of triterpenoidsfromEclipta prostrate on hepatic stel-late cells[J].Phytomedicine,2008,15:775-780.
• [15]江海艳,王春妍.大承气汤对急性肝损伤大鼠TNF2α、IL-6及NO含量的影响[J].吉林中医药,2008,28(11):845-846.
• [16]徐汝明,邓克敏,陆阳.中药墨旱莲扶正固本和保肝作用的研究[J].上海交通大学学报,2009,29(10):1200-1204.
• [17]MKobori,Z Yang,D Gong,et al.Wedelolactone suppresses LPS-induced caspase-11 Expression by directly inhibiting the IKKComplex[J].Cell Death and Differentiation,2004,11:123-130.
• [18]景辉,白秀珍,杨学东,等.墨旱莲对小鼠胸腺细胞凋亡的调节作用[J].数理医药学杂志,2005,18(4):3181.
• [19]D.Christybapita,M.Divyagnaneswari,R.Dinakaran Michael.O-ral administration of Eclipta alba leaf aqueous extract Enhancesthe non-specific immune responses and disease Resistance ofOreochromis mossambicus[J].Fish and Shellfish Immunology,
• [20]Thavasimuthu Citarasu,Veeramani Sivaram,GrasianImmanuel,etal.Influence of selected Indian immunostimulant herbs againstWhite spot syndrome virus(WSSV)infection in black tigershrimp,Penaeus monodon with reference tohaematological,bio-chemical and immunological changes[J].Fish and Shell Im-munology,2006,21:372-384.
• [21]周玲生.墨旱莲对致衰模型小鼠免疫器官保护作用的形态研究[J].现代预防医学,2009,36(3):439-440.
• [22]Dae-IkKima,Sung-HyenLee,Jin-HoChoi.The butanol fraction ofEclipta prostrata(Linn)effectivelyreduces serumlipidlevels andimproves antioxidant activities in CD rats[J].Nutrition Re-search,2008,3(28):550-554.
• [23]C.SanthoshKumari,S.Govindasamy,E.Sukumar.Lipid loweringactivity of Eclipta prostrata in experimental hyperlipidemia[J].Journal of Ethnopharmacology,2006,105:332?335.
• [24]朱玉云,允生,张峰,等.旱莲草水提物对低氧模型小鼠的影响[J].医药导报,2006,25(1):12-15.
• [25]Pimolpan Pithayanukul,Sasitorn Laovachirasuwan,Rapepol Bavo-vada.Anti-venompotential of butanolic extract of Eclipta prostra-ta against Malayan pit viper venom[J].Journal of Ethnopharma-cology,2004,29(90):347-352.
• [26]Luciana C.Diogo,Renata S.Fernandes,Silvana Marcussi,et al.Inhibition of Snake Venoms and Phospholipases A2by Extractsfrom Native and Genetically Modified Eclipta alba:Isolation ofActive Coumestans[J].Basic and Clinical Pharmacology andToxicology,2009,104:293-299.
• [27]Mi Kyeong Lee,Na Ry Ha,Hyekyung Yang,et al.StimulatoryConstituents of Eclipta prostrate on Mouse Osteoblast Differentia-tion[J].Phytotherapy Research,2009,23:129-131.
• [28]Kakali Dattaa,Anu T.Singha,Ashok Mukherjeea,et al.Eclip-taalba extract with potential for hair growth promoting activity[J].Journal of Ethnopharmacology,2009,124:45.
• [29]涂彩霞,张荣鑫,马景昕,等.墨旱莲乙醇提取物动物致色素作用和对小鼠B16黑素瘤细胞黑素生成的影响[J].中国中西医结合皮肤性病学杂志,2006,5(1):1-3.