郑丽红;王馨;王琳晶;王楠楠;王海强;

• 1:黑龙江中医药大学附属第二医院
• 2:黑龙江中医药大学附属第一医院

摘要(Abstract)：

目的探讨愈肠栓对实验性溃疡性结肠炎大鼠炎症因子的影响。方法将实验大鼠随机分为正常对照组、模型组、柳氮磺吡啶栓组、愈肠栓组。治疗2周后,观察大鼠疾病活动指数(DAI)、结肠组织病理改变及血清TNF-α、IL-1β、IL-4、IL-10含量变化。结果与正常对照组比较,模型组大鼠DAI评分、血清中TNF-α、IL-1β水平明显升高,IL-4、IL-10水平明显降低,差异有统计学意义(P <0.01);与模型组比较,柳氮磺吡啶栓组、愈肠栓组DAI评分、TNF-α、IL-1β明显降低,IL-4、及IL-10水平明显升高,差异有统计学意义(P <0.05或P <0.01);柳氮磺吡啶栓组与愈肠栓组比较差异无统计学意义。结论愈肠栓能有效改善TNBS诱导的溃疡性结肠炎模型大鼠症状,其机制可能是通过降低血清炎症因子TNF-α、IL-1β含量,上调抑炎因子IL-4、IL-10的水平,从而达到缓解大鼠溃疡性结肠炎的作用。

关键词(KeyWords)： 愈肠栓;溃疡性结肠炎;炎症因子

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省自然科学基金项目(H2016077);黑龙江省自然科学基金(H2017061);; 黑龙江中医药大学校基金项目(201301);; 黑龙江省卫生计生委科研基金(2018235)

作者(Author): 郑丽红;王馨;王琳晶;王楠楠;王海强;

Email:

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